Importantly, genetic lesions that characterize de novo DLBCL, such as the EZH2 or CREBPP mutations commonly found in the germinal center B-cell-like (GCB) subtype of DLBCL or the perturbations of the B-cell signaling pathway seen in the ABC DLBCL subtype, do not seem to be prevalent in RS DLBCL. The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.