PTK2 and neuroblastoma: Pham et al. [129] observed that neferine disrupted the growth of IMR32 human neuroblastoma cells by the induction of G2/M phase arrest, apoptosis and autophagy, cleavage of caspase-3 and PARP, accumulation of LC3-II, overexpression of Beclin-1, and reduction in phosphorylated FAK (p-FAK) and ribosomal S6 kinase 1 (p-S6K1).