NFKB1 and hepatocellular carcinoma: Shu et al. [117] treated Hep2G, Huh-7 and H22 hepatocellular carcinoma cells with various concentrations of isoliensinine and found that it suppressed proliferation and induced apoptosis through a decrease in NF-κB activity in HCC cells, as well as through decreased phosphorylation of the NF-κB p65 subunit.