In seven of eight triple negative breast cancer cell lines, AHNAK mRNA expression was downregulated, with expression being inversely correlated with tumour status, lymph node status, lymph node infiltration, TNM staging, and prognosis [29]; this tumour-suppressive effect was associated with both the AKT/MAPK and Wnt/β-catenin pathways [29]. The gene discussed is AKT1; the disease is neoplasm.