TYMS and in situ carcinoma: AHNAK2 has a reported association with cisplatin (CIS) and 5-fluorouracil (5-FU) resistance, with 5-FU being used in colon, oesophageal, gastric, pancreatic, and breast cancers through the inhibition of thymidylate synthase (TS) and incorporating its metabolites into RNA and DNA.