Rlip76 (Rlip, the 76 kDa isoform encoded by the RALBP1 gene at human genomic locus 18p11.22) has been well-established by several lines of evidence as a permissivity factor required for oncogenic transformation, cancer growth, and invasion/metastasis [1,2,3,4,5,6,7]. The gene discussed is RALBP1; the disease is cancer.