Therefore, based on our results, we speculate that CXCR2 activation could be used by the metastatic tumors as a mechanism to retard apoptosis and program the tumor-infiltrating TANs into a pro-NETotic state, to assume a unique spatial distribution that assists in the subsequent migration and invasion of the metastatic tumor cells. The gene discussed is CXCR2; the disease is metastatic neoplasm.