The intensity of HK2-positive staining in NOX2-positive staining (Figure S4a–c) and the number of cells showing subcellular co-localization of HK2 and NOX2 were increased in patients with G3 glioma (G3) relative to those in G1 and G2 gliomas (G1, G2) (Figure S4d). This evidence concerns the gene CYBB and central nervous system cancer.