BCR and chronic myelogenous leukemia, BCR-ABL1 positive: In 2018, a BCR-ABL loop involving MYC and miR-150 was described showing that bcr-abl inhibits miR-150 expression in CML cells via the transcriptional activation of MYC and its simultaneous recruitment to a specific locus of the miR-150 gene, where myc binds and acts as a direct repressor of miR-150 transcription [50].