In addition, feedback loops have been identified between microRNA genes and protein-coding genes: TP53 transactivates miR-15a/16-1 and miR-34b/c in CLL [69], and MYC binds and directly inhibits miR-150 transcription in CML [50]. The gene discussed is TP53; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.