RUNX1 and acute leukemia: In addition, miRNA expression profiling can discriminate childhood T- from B-acute lymphoblastic leukemia [93] and cluster acute leukemia samples into three groups corresponding to specific chromosomal rearrangements: (i) BCR-ABL, a hallmark of CML also found in high-risk ALL; (ii) t(12;21)(p13;q22), also known as ETV6/RUNX1 or TEL-AML1 translocation, which is associated with a good outcome; and (iii) MLL1 disruption on chromosome 11q23, which correlates with a poor outcome [94,95,96,97].