Furthermore, our observations in Pep#11/Pep#26-mediated, dramatically reduced tumor growth of recurrent GMB mice models that had been treated with chemotherapeutic cisplatin (Figure 6) may suggest the potential of conquering drug resistance or relapse after chemotherapy by interfering cisplatin-induced MSI1/AGO2 protein complex formation (Figure 4B). This evidence concerns the gene AGO2 and neoplasm.