PIK3CA and head and neck squamous cell carcinoma: The mutation or amplification of PIK3CA, which encodes the phosphatidylinositol 3-kinase alpha (PI3Kα) catalytic subunit, are among the most common genomic aberrations in HNSCC, with 37% (103 of 279) of cases exhibiting one or both alterations in The Cancer Genome Atlas (TCGA) report [1].