TLR4 and neoplasm: Finally, the authors demonstrated that Andro decreased the expression of some representative molecules in a toll-like receptor (TLR)-4 pathway (TLR4, MyD88, pIκBα, pp65, pp50) both in tumour tissue and in cell culture, suggesting that signaling via TLR4/NFκB is the dominant target of Andro in the regulation of melanoma tumorigenesis [112].