After uPA binding, uPAR shifts from an open to an intermediated and then to a closed conformation [41], the last being able to form potent multiprotein cell-signaling complexes which regulate migration, invasion, metastasis, epithelial–mesenchymal transition, stem cell-like properties, survival, release from states of dormancy, chemo-resistance, angiogenesis and vasculogenic mimicry in cancer [10,42,43,44,45,46,47] (Figure 1). Here, PLAUR is linked to cancer.