It has been shown that either uPAR and DII–DIII-SuPAR regulate CXCR4 through FPR1 [83,92], and that the expression of uPAR and CXCR4 is modulated by microRNAs (miR)s in acute myeloid leukemia cells. This evidence concerns the gene CXCR4 and acute myeloid leukemia.