CD4 and breast carcinoma: While the addition of SN to four different dissected primary breast cancer tissue samples did not affect signaling pathway activities in resting CD4+ T cells, the same SN changed pathway activity scores in activated CD4+ T cells: NFκB, and JAK-STAT1/2 and JAK-STAT3 pathway activity decreased, while the activity of the TGFβ pathway increased (Table 2).