ENOX2 and glioblastoma: This effect was accompanied by dose-dependent overproduction of mitochondrial superoxide in glioblastoma cells only (Figure 3D), as well as by a dose-dependent decrease in the levels of the following parameters: mitochondrial membrane potential, NADH, NAD+, succinate, steady-state ATP, intracellular glutathione, total cellular reducing capacity, and tNOX (Figure 3E).