MAP2K3 and neoplasm: Zhang et al. [42] found dehydroeffusol (DHE) in gastric cancer to induce tumor-suppressing endoplasmic reticulum (ER) stress activating the DNA damage-inducible transcript 3 (DDIT3) transcription factor via the MEKK4-MKK3-p38MAPK signaling pathway activation inhibiting MGC803 cell proliferation.