Although the literature indicates oncosuppressive MKK3 functions [37,38], the reported immunohistochemical staining on tumor and normal brain tissues revealed the expression of MKK3/6 and p-MKK3/6 significantly higher in glioblastoma than in the normal brain tissues [37], suggesting that more investigations are required to define the MKK3 roles in this pathology. This evidence concerns the gene MAP2K3 and glioblastoma.