Zhu et al. [37,38] reported the activation of the signaling pathway GMFβ-MKK3/6-p38MAPK in glioblastoma to be involved in the β-elemene-induced G0/G1 cell cycle arrest in human U87 and rat C6 glioblastoma cells, as either the GMFβ (Glia maturation factor β) silencing (siRNA) or MKK3 and MKK6 inhibition (dominant negative vectors), which hampered the β-elemene-induced effects [37,38]. Here, MAP2K3 is linked to glioblastoma.