MAP2K3 and esophageal cancer: The authors showed that ectopic MKK3 expression significantly decreased cell proliferation, colony-forming ability, and invasion, inducing apoptosis in KYSE150 and KYSE520 esophageal cancer cells, whereas MKK3 siRNA depletion or CRIPS/Cas9 knockout induced opposite effects in vitro and in vivo in xenograft models in nude mice [50].