MAP2K3 and hepatocellular carcinoma: In hepatocellular carcinoma (Figure 2A), Wang et al. [43] described MKK3 oncosuppressive functions since its overexpression impaired proliferation and G1 phase cycle arrest by upregulating the CDK4/6 inhibitors (p16INK4A and p15INK4B) in HepG2 and PLC-PRF-5 cells.