In ovarian cancer, Mansouri et al. [48] dissected the roles of MKK3-p38MAPK signaling in driving response to cisplatin, demonstrating that the p38MAPK inhibition (SB202190) strongly hampers cisplatin-induced cell death, whereas ectopic expression of constitutive activated MKK3 induces apoptosis [48]. The gene discussed is MAP2K3; the disease is ovarian cancer.