MAP2K3 and neoplasm: By investigating the molecular mechanisms through which the metastasis-associated protein 2 (MTA2) regulates matrix metalloproteinase 12 (MMP12) in mediating cervical cancer metastasis, Lin et al. [47] identified a negative regulatory crosstalk ASK1/MKK3-p38MAPK/p-Y-box binding protein 1 (YB1) that activated upon MTA2 silencing, and disrupted the binding of AP1 (c-Fos/c-Jun) to MMP12 promoter, thus hampering tumor invasion [47].