In accordance whit the MKK3′s oncogenic role in breast cancer, using a high-throughput screening approach in MCF7 cells to identify cancer-associated protein–protein interactions (PPI), Ivanov and co-authors identified MKK3 as a novel hub protein due to its interaction with several partners, including the oncogenic transcription factor c-Myc. The gene discussed is MAP2K3; the disease is breast carcinoma.