The differences in the amount of PD-1 receptor expression, as well as in the changes in the percentage of individual lymphocytes in T and B lymphocytes, may be useful in determining disease progression as well as providing information regarding the pathogenesis of laryngeal cancer, including a disturbance in the PD-1/PD-L1 pathway and the T cell activation process. Here, CD274 is linked to laryngeal carcinoma.