Additionally, in our analyses, we also showed that the level of PD-1 expression on T and B lymphocytes was significantly higher in the tumor samples as compared to the lymph node samples for the CD19+ B, CD8+ T, and CD4+ T cells, and the level of PD-1 expression on T and B cells was significantly higher in the tumor samples than in the blood samples. The gene discussed is CD4; the disease is neoplasm.