ACTA1 and cancer: It should be emphasized that the alterations E-cadherin/β-catenin complex in the cell membrane are a key fact for the EMT phenomenon development, whereby oral epithelial cells change their polygonal squamous morphology and acquire fibroblast or myofibroblast-like appearance with an expression of mesenchymal markers (vimentin, α-SMA, and FSP1), increase their motility and invasive capacity, and acquire cancer stem cell characteristics [3,8].