For example, in salivary glands, the term “cylindroma” has been used as a synonym of adenoid cystic carcinoma and, while adenoid cystic carcinoma cases of the skin are analogous to their salivary counterparts, with recurrent fusion involving the MYB gene, skin cylindromas represent a distinct tumor entity with frequent CYLD mutation. This evidence concerns the gene CYLD and adenoid cystic carcinoma.