Therefore, the objective of this study was to explore the clinical relevance of the single nucleotide promoter polymorphisms of FNTB (FNTB-173 6G > 5G; FNTB-609 G > C; FNTB-179 T > A) in a comprehensive breast cancer cohort (n = 797) and to investigate how the genetic variability of the FNTB promoter may affect the binding of transcription factors. Here, FNTB is linked to breast cancer.