Next, to confirm that c-Myc was indeed inhibiting the NKG2DL expression in SCLC-N cells through HDAC3, a highly selective HDAC3 inhibitor, RGFP966, was added to block the HDAC3 in H2227 cells after the transfection of MYC-OE. The gene discussed is HDAC3; the disease is small cell lung carcinoma.