Here, the study aimed to identify the c-Myc-dependent mechanism of suppressing NKG2DL expression and innate immune response in SCLC-N and found that c-Myc targeted HDAC3 to deacetylate H3K9ac at NKG2DL promoter and inhibited the transcription of NKG2DL in SCLC-N cells. This evidence concerns the gene MYC and small cell lung carcinoma.