Additionally, the study on the mechanism revealed that c-Myc recruited HDAC3 to deacetylate histone H3K9ac, which was bound to the promoter region of NKG2DL (Figure 4), thereby suppressing the transcription of NKG2DL in SCLC-N cells and inhibiting the cytotoxic effect of NK cells (Figure 2 and Figure 6). Here, MYC is linked to small cell lung carcinoma.