To clarify whether and which subtype of HDAC participated the modulation of c-Myc on NKG2DL expression in SCLC-N cells, we firstly detected the combination of c-Myc and HDAC1, HDAC2, or HDAC3 by Co-IP and found that only HDAC3 substantially interacted with c-Myc in H2227 and H446 cells (Figure 4A and Figure S5A). This evidence concerns the gene HDAC1 and small cell lung carcinoma.