The specific inhibitor of HDAC3, RGFP966, could recover the expression levels of NKG2DL and the susceptibility to the killing by NK cells that down-regulated by the overexpression of MYC (Figure 4), which was consistent with the reports that NKG2DL in SCLC-A subtype cells was suppressed by deacetylation [18]. The gene discussed is HDAC3; the disease is small cell lung carcinoma.