To explore the mechanism of c-Myc inhibiting MICA/B in SCLC, we used ChIP-qPCR assay to perform whether c-Myc directly binds to the promoter region of MICA or MICB. The data showed that c-Myc may not directly bind to the promoter of MICA or MICB in H2227 or H446 cells (Figure 3A). The gene discussed is MICB; the disease is small cell lung carcinoma.