CLN6 and juvenile neuronal ceroid lipofuscinosis: In South Hampshire sheep with neuronal ceroid lipofuscinoses (Batten disease), a causative mutation in the Ceroid Lipofuscinosis Neuronal 6 (CLN6) gene was absent; however, quantitative real-time PCR revealed that CLN6 mRNA expression was one-third lower in affected South Hampshire sheep compared to control sheep [17].