In particular, a linoleic acid metabolite produced by gut lactic acid bacteria, i.e., 10-oxo-12(Z)-octadecenoic acid also referred to as KetoA, was able to augment energy metabolism through the activation of TRPV1 channels, thus protecting mice from diet-induced obesity and ameliorating obesity-associated metabolic disorders [187]. Here, TRPV1 is linked to obesity due to melanocortin 4 receptor deficiency.