CNR2 and obesity due to melanocortin 4 receptor deficiency: Clearly, the overall pro-inflammatory or anti-inflammatory action of AEA depends on the receptors it modulates (respectively, CB1 and GPR55, on the one hand, or TRPV1 and CB2 on the other hand), which in turn might depend on the baseline context under study (such as exercise or the presence or lack of obesity/overweight).