Mouse models of hypertension-related spontaneous ICH are available (8% high-salt diet + the nitric oxide synthase inhibitor L-NAME in drinking water on a double transgenic background of renin and angiotensinogen overexpression3; angiotensin II pump infusion + L-NAME in drinking water + injection of angiotensin II or norepinephrine in C57BL/6 mice).4 The gene discussed is AGT; the disease is hypertensive disorder.