Of these, 5 patients experienced a grade 3 AE of special interest (1 hepatic failure, 1 increased ALT and AST, 1 increased blood bilirubin, 1 hypertension, and 1 increased blood pressure), 2 patients discontinued treatment due to an AE of special interest (1 decreased ejection fraction, 1 increased ALT and AST), and 2 patients interrupted treatment due to an AE of special interest (1 rash, 1 increased gamma‐glutamyl transferase). The gene discussed is GPT; the disease is liver failure.