In tight correlation with these reported dynamics of splenic CD4+ T helper and T follicular helper cells, T cell death (numbers), as measured by FVD+ staining, was minimally represented in the spleens of S. mansoni infected mice in comparison to their non-infected counterparts, further arguing against a key role of these T cell subsets in the depletion of B cells during schistosomiasis (S8F and S8G Fig). Here, CD4 is linked to schistosomiasis.