IFNA1 and chronic hepatitis C virus infection: Intriguingly, previous studies demonstrated induction of miR-192 by IFN-α in Huh7.5 cells and downregulation upon hepatitis C virus infection [35], indicating that miR-192-5p upregulation in serum could be an independent variable for non-response to Peg-IFN and ribavirin treatment in chronic hepatitis C [36].