Theobservation that ghrelin could prevent the degeneration of striataldopaminergic neurons, expressing GHS-R1a, induced by the neurotoxin1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,173 supports the potential of GHS-R1a agonists in the managementof Parkinson’s disease (PD). The gene discussed is GHRL; the disease is Parkinson disease.