Considering thewell-known role of ghrelin in inducing adiposity and stimulating appetite142,143 as well as in the regulation of glucose metabolism,29,144 different active vaccines based on the ghrelin structure have beendeveloped over the years to prevent obesity.145−147 GHS-R1a antagonists or inverse agonists might also represent promisingagents for the management of metabolic diseases. Here, GHSR is linked to metabolic disease.