TRPM8 and neuropathy: The inhibitory action of TRPM8 expressing cold fibres seems to extend to nociception: Hyperalgesia in neuropathy and inflammatory models was antagonized by the TRPM8 agonists menthol or icilin at the affected skin or upon intrathecal administration; these analgesic effects were lost after specific knockdown of TRPM8 by intrathecal antisense oligonucleotides [134].