Up-regulation of expression was observed in endothelial cells after incubation with 200–800 μM PA [5] and in a breast cancer cell line with 50 ng/ml (approximately 15 μM) of EPA and DHA [35], whereas 50 μM [36] and 500 μM [37] of OA down-regulated PTEN in HepG2 cells. Here, PTEN is linked to breast cancer.