(B) Left: principal component analysis of transcriptomics and proteomics of BMDMs treated with macrophage colony-stimulating factor (M-CSF; M0), lipopolysaccharide (LPS; M1), interleukin-4 (IL4; M2), or conditioned media from Kras-Off (3 or 5 days) or Kras-On (TEM) pancreatic ductal adenocarcinoma (PDA) cells; right: intracellular and extracellular metabolomics from media (Dulbecco’s modified Eagle medium, DMEM + 10% FBS), M0, M1, M2, or TEM (Kras-On media was mock treated or boiled before TEM culture). Here, IL4 is linked to pancreatic ductal adenocarcinoma.