GRN and injury: For instance, in the LPS-induced acute lung injury mouse model, miR-34b-5p inhibition alleviates pulmonary inflammation and apoptosis via targeting PGRN [32]; the transfection of miR-340 mimics suppresses pro-inflammatory cytokine secretion to improve the anti-inflammatory impact of dexmedetomidine in LPS-treated microglia BV2 [33].