Specifically, a total of 208 genes expressing interaction partners identified with MaMTH‐HTS were targeted (using 414 siRNAs, 2 for most gene targets) and the effects of their knock‐down on an mCherry‐Flag‐CFTR traffic reporter expressed in CF bronchial epithelial (CFBE) cells were assessed (Dataset EV7). The gene discussed is CFTR; the disease is cystic fibrosis.