CFTR and cystic fibrosis: Interestingly, this effect was not as strong in CF mutant organoids, where FGL2 knockdown only mildly reduced swelling (relative to empty vector control) upon Fsk stimulation in the cells treated with a combination of modulators VX‐661+VX‐445+VX‐770 (TrikaftaTM) to rescue mutant CFTR activity (Fig 6C and E).