IFIH1 and colorectal cancer: Moreover, the combined treatment of patient‐derived colorectal cancer cell lines with the DNMTi 5‐aza‐2′‐deoxycytidine (5‐AZA‐CdR) together with shRNA‐mediated depletion of ADAR1 induces an MDA5‐dependent type I IFN response through the increased expression of IR‐Alu elements that are no longer edited (Mehdipour et al, 2020).