To model IV‐delivery ex vivo, we treated PBMC from healthy donors with reovirus at a multiplicity of infection (MOI) of 1 (approximating the dose used in the clinical trials) and analysed STAT phosphorylation by intracellular staining and flow cytometry in CD56bright and CD56dim NK cells at 8, 24 and 48 h post‐treatment, reasoning that cytokines induced during treatment would take time to accumulate. Here, SOAT1 is linked to infection.