Thus, assuming a classic ‘high‐responder’ immune response gene effect through ability of the HLA‐DRB1*15:01 binding groove to present specific spike epitopes, it is assumed that the epitope(s) in question must be immunodominant and processed for presentation both during infection and vaccination, and thus visualized as part of hybrid‐immunity boosting. The gene discussed is HLA-DRB1; the disease is infection.