TRA2B and cancer: M6A modification is crucial in a variety of cellular processes such as development, cell self-renewal, cell differentiation, DNA damage response, and cancer [29] In 1998, Imai et al. found the first YTH protein when screening TRA-2β (a component of the cleavage complex) interacting protein using the yeast two-hybrid method; this was named YT521-B [30].