HIF1A and colorectal cancer: Moreover, it was found that β-Catenin knockdown removed the enhanced expression of HIF-1α by UBE2Q1 overexpression and reversed the effect of UBE2Q1 on lactate production and glucose uptake in colorectal cancer under hypoxia, suggesting that UBE2Q1-stabilized β-catenin enhances hypoxia-enhanced glycolysis by activating HIF-1α.