The expression of LncRNA RSU1P2 was significantly elevated in liver cancer cell lines HepG2, HCCLM3, Huh7, and Hep3B than that in normal liver cell-line THLE-2, especially in HepG2 and HCCLM3 cells (1.00 ± 0.11 vs 4.32 ± 0.51, 1.00 ± 0.11 vs 5.14 ± 0.68, p < 0.05; Figure 1(a)), which was also significantly up-regulated in liver cancer tissues compared to normal tissues (0.34 ± 0.16 vs 1.11 ± 0.48, p < 0.05; Figure 1(b)). The gene discussed is RSU1P2; the disease is liver cancer.