Interestingly, Diazzi et al (2022) show that TGFβ, the most potent inducer of EMT in cancer and fibrosis, activates miR‐143‐/145 cluster expression in melanoma cells and that TGFβ can also activate MRTFA expression in non‐small lung cancer cells (Du et al, 2015), linking these two central players now described to lead to MAPKi resistance and fibrosis. Here, TGFB1 is linked to cancer.