Conversely, treatment of mesenchymal BRAFi‐resistant M238R cells with BIBF1120 but also with the TGF‐β receptor inhibitor SB431542, the pan‐AKT inhibitor GSK690693 or the PDGFR inhibitor CP673451 significantly decreased the expression of the two mature miRNAs (Figs 2E and EV2H), indicating that both PDGF and TGF‐β pathways control the expression of the miR‐143/‐145 cluster in melanoma cells. The gene discussed is AKT1; the disease is melanoma.