Given the critical role of RTK upregulation such as PDGFRβ and of the pro‐fibrotic TGF‐β signaling pathway overactivation in mesenchymal resistance (Nazarian et al, 2010; Sun et al, 2014; Diazzi et al, 2020; Girard et al, 2020), we stimulated MAPKi‐sensitive melanoma cells with PDGF‐BB or with TGF‐β and analyzed miR‐143‐3p and miR‐145‐5p expression. The gene discussed is TGFB1; the disease is melanoma.