TAOK2 and schizophrenia: Rs13107325 has been associated with weight gain,29 lipid dysfunction,68 changes in brain volume,69 and brain metal homeostasis, the latter of which may influence schizophrenia risk.70 Finally, two variants, rs3814883 in TAOK2 and rs11191514 in CNNM2, are each associated with schizophrenia,71,72 and both are associated with increased risks of cardiometabolic and cardiovascular disorders.42,73