FURIN and coronary artery disorder: A recent GWAS found a significant association between rs17514846 and CAD,64 and rs17514846 has been shown to regulate FURIN expression in monocytes, which modulates their migration and proliferation in atherosclerotic plaques.65 Furthermore, rs17514846 is in high-LD with rs4702, a genome-wide significant variant for schizophrenia66 which lies in the 3′ untranslated region of FURIN leading to reduced gene expression and impaired BDNF secretion.67