Despite advancements in dialysis technology and treatment for chronic kidney disease (CKD), patients with progressive disease develop complications, including derangements of the bone and mineral metabolism that present as abnormalities in parathyroid hormone (PTH), vitamin D, Ca, and P. These bone and mineral metabolic alterations lead to bone lesions and various diseases3,4 and predispose patients to a high risk of cardiovascular calcifications.4 The gene discussed is PTH; the disease is chronic kidney disease.