Since 12-day administration of losartan or both losartan and lisinopril induced an increase in cardiac Angiotensin Converting Enzyme 2 (ACE2) mRNA and in cardiac membrane ACE2 activity in rats (49), it was hypothesized that ACEIs and ARBs could increase the entrance receptors for SARS-CoV-2 infection leading to a more severe infection and higher mortality. The gene discussed is ACE2; the disease is infection.