Here, as compared with UIAs without AWE, a higher aneurysm wall remodeling ratio (14/20 in UIAs without AWE, and 14/14 in UIAs with AWE), severer inflammation (CD68 and MMP2) and larger atherosclerosis area could be found in UIAs with AWE (Figures 3A–D). The gene discussed is MMP2; the disease is atherosclerosis.