PIR and colorectal carcinoma: Furthermore, piR-823 was shown to enhance glucose-6-phosphate dehydrogenase (G6PD) expression to promote glucose consumption in CRC cells and downregulate the content of intracellular reactive oxygen species (ROS) by suppressing the ubiquitination of hypoxia-inducible factor-1α (HIF-1α) (Feng et al., 2020).