DHTKD1 and neoplasm: In an independent effort to apply TRAIL towards enhancing adenovirus-based OV potency, Zhu et al. (2013) combined two modifications of the E1 region of adenovirus to increase the specificity of virus replication to tumor cells: placing adenoviral genes E1A and E1B under the control of hTERT promoter and HRE (hypoxia response element) respectively.