The new armed virus Ad5/3-E2F-d24-hTNFa-IRES-hIL2 (or OAd.TNFa-IL-2) with the transgenes incorporated into the E3 region, showed a significant reduction in tumor growth in an HapT1 immunocompetent Syrian hamster model relative to control unarmed virus (OAd). This evidence concerns the gene TNF and neoplasm.