IL6 and COVID-19: Type I interferons are crucial for restricting responses during the early stage of SARS-CoV-2 infection, however, IFN-I signaling was dampened in patients with severe COVID-19 (Blanco-Melo et al., 2020), and low level of IFNs along with an increase in IL-6, have been detected in the peripheral blood samples or lungs of patients (Hadjadj et al., 2020).