VSTM2L was shown to be downregulated in Helicobacter pylori-positive gastric cancer compared to corresponding normal tissues (Hu et al., 2018); additionally, the CpG island methylation phenotype (CIMP)-related gene signature comprising VSTM2L and five other genes showed prognostic value in gastric cancer (Zeng et al., 2020). The gene discussed is VSTM2L; the disease is gastric cancer.