NCF2 regulates the antiapoptotic role of p53 in cancer cells exhibited by increased apoptosis due to loss of NCF2 and the associated upregulation of ATXN1 during VSTM2L overexpression suggested a link with cancer regulation (Lee et al., 2009; Rajaraman et al., 2009; Siliņa et al., 2011; Didonna et al., 2020). This evidence concerns the gene VSTM2L and cancer.