To address this point, in this study we used multiple databases, including TCGA, GEO, CCLE, HPA, TIMER, GTEx, and TISIDB in combination with Kaplan–Meier Plotter to perform a comprehensive and multidimensional pan-cancer analysis of the role of VSTM2L. We compared VSTM2L expression in different types of cancer and corresponding normal tissue. Here, VSTM2L is linked to cancer.