High VSTM2L expression was also related to advanced tumor status (T2 vs T3, p = .0018; T2 vs. T4, p = .00053) and node status (N0 vs N2, p = .0074; N0 vs. N3, p = .017) in STAD patients irrespective of sex and age. Here, VSTM2L is linked to gastric adenocarcinoma.