On multivariate analysis, tumor size (OR = 0.439, p < 0.001), and interval time between NCRT and surgery (OR = 1.241, p = 0.003), and post-NCRT CEA (OR = 0.880, p = 0.008) were significant risk factors for pCR in patients with LARC (Table 3). The gene discussed is CEACAM5; the disease is neoplasm.