The results of the present study showed that F. velutipes polysaccharide may alleviate CTX-induced oxidative stress capacity as well as increase the body's iron uptake and immune response through upregulation of TFRC and RSAD2 protein expression, and exert immune modulatory effects through drug metabolism-related pathways such as immune diseases, transport and catabolism, phagosomes and influenza A. This evidence concerns the gene RSAD2 and immune system disorder.