Liang et al. (59) used proteomics to find that Nigella sativa seed polysaccharides could participate in immune regulation by regulating metabolism-related pathways such as Autoimmune thyroid disease, Primary immunodeficiency, and PI3K-Akt signaling pathway through the regulation of differential proteins such as PI3K and PTEN. Here, AKT1 is linked to autoimmune thyroid disease.