However, when assessing the composite of critical COVID-19 using logistic regression models, lower vitamin D levels were associated with critical COVID-19 (OR 0.97, 95%CI 0.94, 0.99, p = 0.042, adjusting by age, gender, BMI, C-reactive protein, D-dimer, CKD, SpO2 or T2D status). This evidence concerns the gene CRP and chronic kidney disease.